Early postoperative inflammation can pose challenges following cataract surgery. Various anti-inflammatory regimens have been explored, but their comparative efficacy and safety remain subjects of debate.
This study conducted a randomized controlled trial involving participants undergoing standard cataract surgery. Five prophylactic regimens were examined: combinations of prednisolone and ketorolac eyedrops, ketorolac eyedrops alone, or dropless surgery with sub-tenon dexamethasone. Participants were randomly assigned to these regimens and assessed for changes in anterior chamber flare, visual acuity, intraocular pressure (IOP), and adverse events.
The study reveals that Metformin exhibits a slightly higher improvement rate in menstrual cycle regularity. Conversely, Myo-inositol demonstrates a modestly higher rate of symptomatic improvement, encompassing factors such as cyst morphology, hirsutism, mean weight reduction, and enhancement.
This study provides valuable insights into early postoperative inflammation management after standard cataract surgery. Monotherapy with NSAID eyedrops may be preferable to the combination of steroid and NSAID eyedrops. Further research is needed to assess long-term effects. The rigorous study design and comprehensive outcomes analysis ensure the reliability of the conclusions, aiding clinicians in selecting the most suitable prophylaxis regimen.
